CBL offers pathologist-directed laser capture microdissection (LCM) services. This innovative technology allows for the isolation of single specific cells of interest (e.g. tumor or stromal cells) from fresh frozen or FFPE tissue sections under microscopic supervision.
Services can be performed from either using tissue blocks or prepared sections that are provided by the client. Cells of interest can be harvested either directly or by isolating them by removing unwanted surrounding cells and structures.
In addition, methods for preparing protein lysate preparations from either frozen or formalin-fixed, paraffin-embedded (FFPE) samples are available.
LCM services for isolating cells can be performed as part of an integrated service that involves genomics and or proteomic analysis, or can be provided as a stand-alone service in situations where the investigator prefers to conduct their own internal analysis of the LCM-prepared materials.
Further analytical services provided are:
Isolation of DNA and RNA
PCR-based detection of mutations and DNA/RNA sequencing
Preparation of protein lysates
Combination of LCM and proteomics
Please visit Molecular Biology Service Page for our offered detailed services using cells collected after LCM.